报告标题:High-Symmetry Molecular Architectures: Turning Aesthetics into
Stability and Functionality报 告 人:Dr. Aleksandar Kondinski
(Department of Chemistry, KU Leuven)报告时间:
dilemma whether chemists should strive towards preparation of nature
-mimicking functional assemblies or should they strive towards the
preparation of idealized molecular architectures with little value
besides their aesthetic appeal, has been puzzling many chemists among
which the Nobel Laureate Roald 霍夫曼n. In this seminar we will reveal
how the concepts of high symmetry can affect the discovery of structural
trends among molecular metal-oxides and how once employed it leads to
allocation of viable synthetic targets with anomalous stabilities and
desired functionalities. The seminar touches aspects of cluster
isomerism and strain effects rising from the match of two different
building blocks. Finally, the seminar reveals how inexpensive resources
can be employed in discovery-based learning of complex topics on
polyhedral and reticular topologies with chemical
relevance.报告人简要介绍:Dr. Aleksandar Kondinski is currently a FWO
Postdoctoral Fellow at the Laboratory of Bioinorganic Chemistry (KU


报告标题:Molecular Force Sensors: from molecular mechanisms towards
applications in biology and materials science 报 告 人:Kerstin G.
systems are highly sophisticated smart materials. They are
stimuli-responsive and possess impressive self-reporting and
self-healing properties. They are consequently an important source of
inspiration for materials scientists who aim to implement these
properties in synthetic and biomimetic materials. In this context, we
are specifically interested in (bio)molecules that act as molecular
force sensors. In biological systems, these sensors detect a mechanical
stimulus and convert it into a biochemical signal. Mimicking their
natural counterparts, a number of different force sensors have been
designed and synthesized in recent years that generate an optical output
(fluorescence). Following a calibration of their mechanical properties,
these artificial force sensors can report on molecular forces in situ in
a highly sensitive manner.In this lecture, I will summarize our efforts
towards designing and characterizing molecular force sensors, focusing
on two classes of force sensors that are based on fundamentally
different molecular mechanisms: The first class utilizes biological
molecules that form thermodynamically stable, non-covalent interactions,
such as short, double-stranded DNA duplexes or coiled coil interactions.
These force sensors report on forces in the range between 十-200
piconewton, making them ideal candidates for applications in biological
systems. The second class is based on covalent bonds, which require
forces above 400 pN to become activated. One example is the mechanical
activation of triazoles as they are formed in a typical click chemistry
reaction. With these molecular force sensors at hand, our goal is to
utilize these sensors for detecting cellular traction forces or for
visualizing force propagation pathways in polymeric
materials.报告人简单介绍:Kerstin Blank studied Biotechnology at the
University of Applied Sciences in Jena and obtained her diploma in 三千.
After 叁 years as a project manager in Industry, she returned to
Academia. Under supervision of Prof 赫尔曼 Gaub at Ludwig-马克西米利安s
Universität in Munich she earned her PhD in Biophysics in 2006. After
two short postdoctoral stays with Prof Andrew 格里福s (Université de
Strasbourg) and Prof Johan Hofkens (Katholieke Universiteit Leuven), she
became assistant professor at Radboud University in Nijmegen in 二零零六. In
201肆, she moved to the 马克斯 Planck Institute of Colloids and Interfaces
where she holds the position of a 马克斯 Planck Research Group Leader. Her
research interests combine her background in biochemistry and single
molecule biophysics with the goal of developing molecular force sensors
for biological and materials science applications.附属类小部件:无

告知标题:Advanced materials by externally controlled ATRP

Clinic)迈克尔 J.

Blank大学生学术报告会的布告,Matyjaszewski助教学术报告会的通报。报 告 人:Professor Krzysztof Matyjaszewski (Carnegie Mellon University)

  1. 报告时间:20壹7年12月十六日(周2)午夜9:00从头


告诉地方:华工发光材质与器件国家首要实验室(北区科技(science and technology)园一号楼)W50二会议室


  1. 告知内容:


告诉标题1:Biofabrication and Commercialization of Tissue
Engineering/Regenerative Medicine Products


报告人:Dr. Michael J. Yaszemski,美国Mayo Clinic


报告标题二:Genetically Encoded Click Chemistry: New Tools for
Protein-based Materials



The Atom Transfer Radical Polymerization (ATRP) process developed at
Carnegie Mellon by Professor Krzysztof Matyjaszewski in 1994 is among
the most effective and most widely used methods of conducting a
controlled radical polymerization (CRP). The Matyjaszewski Polymer Group
continues to improve ATRP and prepare materials with controlled topology
and composition suited for many applications, including automotive,
building materials, medical, military and environmental fields using
this robust technology.

告知标题三:Hydrogen-Bonded Polymer Complex Fiber: Elastic, Conductive
and Self-healing



Kris Matyjaszewski is J.C. Warner University Professor of Natural
Sciences at Carnegie Mellon University. He discovered Cu-mediated atom
transfer radical polymerization, commercialized in 2004 in US, Japan and
Europe. He has co-authored >1000 publications (cited >126,000
times, h-index 171, Google Scholar) and holds 59 US patents.
Matyjaszewski received 2017 Franklin Medal in Chemistry, 2015 Dreyfus
Prize in Chemical Sciences, 2014 National Institute of Materials Science
(Japan) Award, 2011 Wolf Prize in Chemistry, 2009 Presidential Green
Chemistry Challenge Award, and from the ACS: 2015 Overberger Prize, 2013
AkzoNobel North America Science Award, 2011 Hermann Mark Award, 2011
Award in Applied Polymer Science, 2002 Polymer Chemistry Award, 1995
Creative Polymer Chemistry Award. He received 10 honorary degrees and is
a member of National Academy of Engineering, Polish Academy of Sciences,
Russian Academy of Sciences, and National Academy of Inventors.

报告标题四:Tumor-acidity activated nanomedicine for cancer therapy



告诉标题5:X-ray and Neutron Scattering Studies of Giant Molecular


告诉标题六:Microparticle Templating as a Route to Nanoscale Polymer
Vesicles with Controlled Size Distribution






  1. Biofabrication and Commercialization of Tissue
    Engineering/Regenerative Medicine Product(Dr.Michael J. Yaszemski)

报告人简单介绍:Dr. 迈克尔 J. Yaszemski is the Krehbiel Family Endowed
Professor of Orthopedic Surgery and Biomedical Engineering at the Mayo
Clinic and director of its Polymeric Biomaterials and Tissue Engineering
Laboratory. He served as president of the Mayo Clinic medical staff from
20一叁-201四, and had served for 拾 years as the Chair of the Spine Surgery
Division of the Department of Orthopedic Surgery at Mayo Clinic
Rochester prior to entering the presidential line. He received both
巴赫elors and Masters degrees in Chemical Engineering from Lehigh
University in 1977 and 一九七七, an M.D. from 吉优rgetown University in 1玖8叁and a Ph.D. in Chemical Engineering from the Massachusetts Institute of
Technology in 199五. He organized and then served as the first Chair of
the Musculoskeletal Tissue Engineering study section at NIH, and served
as a member of the Advisory Council of the NIH National Institute of
Biomedical Imaging and Bioengineering from 20拾-201四. He is currently a
member of the NIH Advisory Council of the National Institute of
Arthritis, Musculoskeletal, and Skin Diseases. He served as Chair of the
FDA Center for Devices and Radiologic Health Advisory Committee, and is
currently a member of the FDA Science Board. He is an emeritus member of
the Lehigh University Board of Trustees. His clinical practice
encompasses spine surgery and musculoskeletal oncology. His research
interests are in the synthesis and characterization of novel degradable
polymers for use in bone regeneration, cartilage regeneration, nervous
tissue regeneration, and controlled delivery of chemotherapeutic agents
to musculoskeletal tumors.

  1. 美高梅4858官方网站,Genetically Encoded Click Chemistry: New Tools for Protein-based

内容摘要:Genetically encoded chemistry provides versatile control over
the process of chemical reactions and the resulting materials. The
spontaneous formation of an isopeptide bond between a peptide tag and
its protein partner is a genetically encoded, cell-compatible, highly
specific and efficient chemistry for protein/peptide conjugation, as
demonstrated in the chemically reactive pair of SpyTag/SpyCatcher. In
this talk, I will give a brief overview of our work in the development
of genetically encoded protein chemistry tools (especially those
possessing features of click chemistry) and the use of such tools to
create bioactive materials. Through protein engineering, we have
successfully developed a chemical toolbox of genetically encoded
chemical reactions. The possibility to encode chemical information into
protein sequences has allowed the direct cellular synthesis of cyclic
proteins, tadpole proteins, star proteins, and other branched
topologies. The reaction between proteins bearing multiple reactive
groups also lead to all-protein-based bioactive hydrogels, whose
macroscopic properties are fully genetically encodable. By combining
this chemistry with protein folding, protein catenanes and other complex
protein topologies can be prepared.4 In general, catenation was found to
increase proteins stability toward proteolytic digestion and thermal
denaturation. It has thus opened new ways to engineer proteins
properties, both in 酷派 and in vitro.

报告人简单介绍:Wen-Bin Zhang is currently an Assistant Professor at the
Department of Polymer Science and Engineering, College of Chemistry and
Molecular Engineering of Peking University. He received his B.S. in
Organic Chemistry from Peking University in 2004 and his Ph.D. in
Polymer Science from the University of Akron in 20拾. He continued at
the University of Akron for his postdoctoral research under the
supervision of Prof. 斯蒂芬 Cheng for one year, before he moved to
Caltech for a second postdoctoral training with Prof. 戴维 Tirrell in
Protein Engineering and Biomaterials. His current research interests
include the rational development of materials that bridges synthetic
systems and biological systems for energy and health-related
applications. In particular, he is interested in developing genetically
encoded protein click chemistry and the use of such tools for protein
topology engineering and protein-based bioactive materials.

  1. Hydrogen-Bonded Polymer Complex Fiber: Elastic, Conductive and

内容摘要:Polymer complex is a highly miscible aggregation of different
polymers. Polymer complexes can be divided into different types
according to the molecular interaction, such as polyelectrolyte complex
and hydrogen-bonded complex. We develop special methods to prepare
hydrogen-bonded polymer complex into fibers. First, a spinnable fluid is
obtained by restricting hydrogen bonds, and then it is extruded through
a spinneret into a coagulation bath where hydrogen bonds are built to
make fiber formation. Utilizing hydrogen-bonded polymer complex, we
produce elastic, self-healing and conductive fibers, which show
potential applications in flexible electronics.

报告人简要介绍:Prof. Shuguang Yang received his BS of Chemistry (二〇〇四) at
Wuhan University and PhD of Polymer Science (200七) at Institute of
Chemistry, Chinese Academy of Sciences (CAS). He was research assistant
(二〇〇五-二〇一〇) in Department of Polymer Science and Engineering, Peking
University, and Postdoc Research Associate (二〇〇八-20十) in Department of
Polymer Science, University of Akron. He has been professor of Material
Science and Engineering since 2010, and associated director of Center
for Advanced Low-dimension Materials, Donghua University since 201陆. His
academic interest is on structure and dynamics of low-dimension
materials and his research is polymer complexes, coacervates, films,
membrane and fibers.



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